Rejuran Salmon DNA: Understanding Polynucleotides (PN) vs PDRN

The aesthetic and dermatology world is buzzing with regenerative treatments that go beyond the surface. One standout innovation is Rejuran, a treatment derived from salmon DNA—specifically polynucleotides (PN) and PDRN (Polydeoxyribonucleotide).

Although they are both utilized in skin rejuvenation therapies, polynucleotides (PN) and polydeoxyribonucleotides (PDRN) have different molecular structures and compositions. A form of PN known as PDRN is made up of DNA fragments, whereas PN can contain both DNA and RNA. In general, PN is thought to have larger concentrations and more restorative qualities than PDRN.

These molecules have gained immense popularity for their anti-aging, skin-repairing, and rejuvenating effects. But what exactly are PN and PDRN, and how do they differ? Let’s break it down.

What Is Rejuran?

Originally from South Korea, Rejuran is a skin-rejuvenating treatment that uses polynucleotides (PN) made from salmon DNA. The elasticity, texture, and general appearance of the skin are all improved by these PN molecules, which aid in cellular regeneration and repair. Rejuran encourages the body's natural healing processes, which increases the creation of collagen and improves skin moisture, in contrast to fillers or Botox.

What Are Polynucleotides (PN)?

Polynucleotides are long chains of nucleotides—the building blocks of DNA and RNA. In skin therapy, they serve a bioregenerative function acting as cellular messengers, promoting fibroblast activity, increasing collagen and elastin and restoring the skin’s extracellular matrix.  PNs extracted from salmon DNA are highly biocompatible and offer several benefits:

• Stimulate fibroblast activity (cells that produce collagen and elastin)

• Promote tissue repair and cell regeneration

• Improve skin elasticity, hydration, and barrier function

• Reduce inflammation and oxidative stress

Polynucleotides act on a deeper, cellular level, promoting dermal remodeling over time. They're often considered the next-generation regenerative molecule in injectables.

Aesthetic Uses of Polynucleotides:

 Combination with Energy-Based Devices

• Pre- or post-treatment with lasers, RF microneedling, or HIFU.

• Enhances healing, reduces downtime, and maximizes results.

 Preventative Anti-Aging

• Used in younger clients to maintain skin integrity and prevent premature aging.

• Restores optimal skin health in subtle, natural ways.

What Is PDRN?

PDRN (Polydeoxyribonucleotide) is a subset of polynucleotides—shorter DNA fragments and ultimately a smaller molecule. It is also derived from salmon sperm and has been used medically for over a decade for its wound healing, anti-inflammatory and tissue repair properties.  

In cosmetic treatments, PDRN:

• Speeds up tissue repair

• Stimulates angiogenesis (formation of new blood vessels)

• Offers anti-inflammatory effects

• Aids in post-procedure recovery

Because it’s a smaller molecule compared to PN, PDRN is often more focused on healing and soothing, whereas PN goes a step further to regenerate and restructure the skin matrix.

Aesthetic Uses of PDRN:

Post-Procedure Healing

• Applied topically or injected after lasers, chemical peels, microneedling, or thread lifts.

• Speeds up skin recovery, reduces redness, and soothes inflammation.

Skinboosters and Hydration Therapy

• Often found in injectable serums or ampoules.

• Restores hydration and calms stressed or reactive skin.

Treatment of Sensitive or Compromised Skin

• Ideal for rosacea-prone, thin, or post-acne skin.

• Improves microcirculation, reduces TEWL (transepidermal water loss), and encourages barrier repair.

Key Differences Between PN and PDRN

Both PN and PDRN are groundbreaking tools being used in regenerative aesthetics, and Rejuran is a trailblazer in bringing these molecules into treatment rooms and mainstream skin care becoming some of the most sought-after treatments for anti-aging and overall skin wellness.  

Side Effects & Concerns

PDRN and PN side effects are usually mild, going away in a few days, and are usually brought on by the way the medication is administered rather than the substance itself. Redness, swelling, moderate bruising, needle marks, and skin lumps are possible side effects of injections. Redness, mild swelling, and pinprick bleeding are possible side effects of microchanneling or microneedling.

A transient histamine reaction may result from either treatment. This can be lessened by taking Benadryl, staying hydrated, and getting enough sleep.

Since fish allergies are brought on by the body's immunological reaction to fish proteins, they shouldn't be a problem. Deeply filtered stem cells taken from salmon sperm DNA make up PDRN. A person should consult an allergist for confirmation if they are worried about their seafood allergy.

Key Benefits of PN vs PDRN

Both PN (Polynucleotides) and PDRN (Polydeoxyribonucleotides) share several valuable benefits when it comes to rejuvenating facial skin. These injectable skin boosters are widely appreciated for their ability to:

• Deeply hydrate and improve skin elasticity

• Smooth out fine lines and wrinkles

• Brighten the complexion for a more even tone

• Refine skin texture, leaving it softer and smoother

• Stimulate natural collagen production

• Support skin repair and regeneration

Thanks to these effects, PN and PDRN treatments have become popular choices not only for the face but also for the neck, décolleté, and hands—offering noticeable anti-aging results without invasive procedures.

PN-Specific Benefits

PN formulas are highly concentrated, making them especially effective for more severe skin aging. They offer:

• More dramatic and longer-lasting improvements, ideal for deeply aged skin

• Enhanced rejuvenation for delicate areas like under the eyes

• The option to use stronger concentrations tailored to advanced concerns such as deep wrinkles

Because of its rich polynucleotide content, PN is perfect for those seeking intensive anti-aging treatments with customizable strength depending on skin damage and goals.

PDRN-Specific Benefits

On the other hand, PDRN solutions typically contain lower polynucleotide levels but bring additional perks, including:

• Being well-suited for mild to moderate skin issues

• Infusion of hydrating and soothing ingredients like hyaluronic acid to help reduce inflammation

• A gentler approach that can be better for sensitive skin types

For many, PDRN offers a balanced solution that encourages skin renewal while nourishing and calming the skin, making it a great choice for overall skin health and subtle rejuvenation.

Which Treatment to Choose?

Higher polynucleotide concentrations in PN provide potent anti-aging benefits.

To address a range of issues, PDRN contains moisturizing and calming substances along with moderate polynucleotide levels.

For severe wrinkles and loose skin, PN can be the best option.

A broader spectrum of people, especially those with sensitive skin, may benefit from PDRN.

For specific objectives, treatment programs can be tailored to include the best possible product selection and strength, duration, and cost.

There isn't a choice that is always better. The most crucial stage is seeking the advice of a skilled cosmetic dermatologist in NYC for their professional treatment plan and product recommendations. Ultimately, consulting with a skincare professional can help determine which treatment suits your unique needs best, ensuring you get the right balance of results and comfort.

Frequently Asked Questions

1. Is Rejuran PDRN or pn?

Because RJRN Booster is a concentrated and purified version of PDRN, it is an injectable PN skinbooster with improved regeneration qualities. Originating from the DNA of salmon, it is extremely biocompatible and appropriate for the majority of people.

2. Is polynucleotide the same as Rejuran?

However, polynucleotides (PN) made from salmon DNA are used in polynucleotide treatment, also referred to as Rejuran Healer. These polynucleotides are well-known for their regenerative qualities; they enhance suppleness and encourage skin restoration at the cellular level.

3. Is pdrn exosome?

Exosomes serve as skin cell messengers, and polydeoxyribonucleotides (PDRN) stimulate fibroblast growth and activity.

4. Is one session of polynucleotides enough?

Professionals advise a course of two to three treatments spaced three to four weeks apart, with maintenance treatments every six to twelve months, to maintain results. Long-term collagen stimulation and continuous skin improvement result from this.